ASCL5

Across TCGA pan-cancer cohorts, ASCL5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ASCL5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ASCL5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ASCL5 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, KIRC, and THCA are the cancer types where ASCL5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASCL5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+1.390	<.001	12	view →
KIRC	All	All	+0.205	<.001	10	view →
THCA	All	II,III,IV	+0.519	<.001	9	view →
BLCA	Female	III,IV	+0.451	.001	8	view →
KIRP	Male	II,III,IV	+0.330	<.001	8	view →
LUAD	All	All	+0.445	<.001	6	view →
LIHC	All	All	+0.056	<.001	6	view →
CHOL	All	All	+0.686	<.001	4	view →
STAD	All	All	+0.329	.004	4	view →
BRCA	All	II,III,IV	+0.106	.001	4	view →
UCEC	All	All	+0.906	.004	2	view →
READ	All	All	+1.113	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ASCL5–COAD

Open the COAD breakdown →