Across TCGA cell cohorts, ASCL4 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASCL4-associated genes across cancer lineages are PRSS54, DEUP1, and OR2T33. Each is linked with ASCL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASCL4-to-partner and partner-to-ASCL4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL4→partner) and Y-score (partner→ASCL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRSS54 →	+0.030	+3.345	<.001	.001	3	1
LARGE_INTESTINE	DEUP1 →	+0.318	+3.832	<.001	.001	3	1
LARGE_INTESTINE	OR2T33 →	+0.109	+2.716	.006	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.109	+3.425	.003	<.001	3	1
LARGE_INTESTINE	CLPSL1 →	+0.098	+2.791	.001	.005	3	1
LARGE_INTESTINE	CEACAM16 →	+0.072	+2.841	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

ASCL4 survival (RNA) · tumor vs normal (RNA) · all ASCL4 data types