ASCC3

Across TCGA pan-cancer cohorts, ASCC3 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated ASCC3 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ASCC3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ASCC3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, UCEC, and COAD are the cancer types where ASCC3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.425	0.875	<.001	66	view →
UCEC	DFS	Median	All	0.979	0.605	<.001	36	view →
COAD	OS	Median	All	0.632	0.875	<.001	33	view →
LIHC	OS	Median	II,III,IV	0.051	0.716	<.001	30	view →
CESC	OS	Median	II,III,IV	0.100	0.555	.003	28	view →
ESCA	DFS	Median	All	0.080	0.533	<.001	18	view →
LUSC	OS	Median	III,IV	0.319	0.711	.003	10	view →
PRAD	OS	Median	All	0.781	0.990	<.001	6	view →
KIRP	OS	Median	All	0.192	0.705	.015	4	view →
GBM	OS	Median	All	0.121	0.415	.042	3	view →
SKCM	DFS	Median	IV	0.040	0.432	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

ASCC3–KIRC (OS)

Open the KIRC breakdown →