ASCC3

Across TCGA patient cohorts, ASCC3 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASCC3-associated genes across cancer lineages are A-Raf_pS299, eEF2, and EGFR_pY1068. Each is linked with ASCC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ASCC3-to-partner and partner-to-ASCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ASCC3-low versus ASCC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCC3→partner) and Y-score (partner→ASCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.121	-1.807	<.001	.003	3	4
UCEC	eEF2 →	+0.279	+2.502	.004	.001	3	3
UCEC	EGFR_pY1068 →	-0.223	-1.836	.001	.001	3	3
UCEC	ERK2 →	+0.180	+2.169	<.001	.002	3	3
UCEC	ASNS →	+0.312	+1.362	.001	.031	3	3
UCEC	Caspase-7-cleavedD198 →	+0.517	+2.321	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

A-Raf_pS299 by ASCC3 expression — UCEC

Explore this box plot interactively →