ASCC3

Across TCGA cell cohorts, ASCC3 mutation is significantly associated with the mutation status of many other genes, with 5,682 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASCC3-associated genes across cancer lineages are PAPPA, SPEG, and CACNA1A. Each is linked with ASCC3 in more than 6 cancer types. Because this analysis shows association rather than direction, both ASCC3-to-partner and partner-to-ASCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAPPA grouped by ASCC3-low versus ASCC3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCC3→partner) and Y-score (partner→ASCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PAPPA →	+3.659	+3.659	<.001	<.001	1	7
BLOOD_Lymphoma	SPEG →	+3.015	+3.015	.003	.003	1	7
BLOOD_Leukemia	CACNA1A →	+2.650	+2.960	.001	.001	1	6
BLOOD_Leukemia	ZNRF3 →	+5.083	+3.672	.001	.001	1	6
LUNG_NSCLC_LUAD	SYNE2 →	+1.851	+3.102	.003	.003	1	5
STOMACH	MYLK →	+2.700	+3.209	.005	.005	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,682 associations by consensus.

PAPPA by ASCC3 expression — BLOOD_Lymphoma

Explore this box plot interactively →