ASB16

Across TCGA cell cohorts, ASB16 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASB16-associated genes across cancer lineages are HHLA1, TAS2R1, and RNF133. Each is linked with ASB16 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB16-to-partner and partner-to-ASB16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HHLA1 grouped by ASB16-low versus ASB16-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB16→partner) and Y-score (partner→ASB16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	TAS2R1 →	+0.025	+3.874	.008	.005	3	1
BLOOD_Leukemia	RNF133 →	+0.057	+3.705	<.001	.007	3	1
BLOOD_Leukemia	KHDC3L →	+0.257	+3.774	<.001	.008	3	1
BLOOD_Leukemia	TSSK1B →	+0.011	+3.874	<.001	.005	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

HHLA1 by ASB16 expression — BLOOD_Leukemia

Explore this box plot interactively →