Across TCGA patient cohorts, AS3MT mutation is significantly associated with the RNA expression of many other genes, with 119 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible AS3MT-associated genes across cancer lineages are SEPTIN7P5, RNA5SP248, and RNA5SP415. Each is linked with AS3MT in more than 1 cancer types. Because this analysis shows association rather than direction, both AS3MT-to-partner and partner-to-AS3MT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AS3MT→partner) and Y-score (partner→AS3MT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SEPTIN7P5 →	+0.060	+4.614	<.001	.006	3	2
UCEC	RNA5SP248 →	+0.360	+2.597	.003	.004	3	2
UCEC	RNA5SP415 →	+0.741	+2.681	<.001	.008	3	2
SKCM	RPL7P31 →	+0.073	+4.351	<.001	.002	3	1
SKCM	HNRNPA1P29 →	+0.040	+3.913	.006	.006	3	1
SKCM	HIGD1AP12 →	+0.150	+4.711	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 119 associations by consensus.

Exploration

AS3MT survival (RNA) · tumor vs normal (RNA) · all AS3MT data types