ARX

Across TCGA patient cohorts, ARX mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARX-associated genes across cancer lineages are ACC_pS79, ACC1, and Cyclin-B1. Each is linked with ARX in more than 1 cancer types. Because this analysis shows association rather than direction, both ARX-to-partner and partner-to-ARX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by ARX-low versus ARX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARX→partner) and Y-score (partner→ARX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.410	+2.459	.014	.020	3	2
UCEC	ACC1 →	+0.616	+2.459	<.001	.020	3	2
UCEC	Cyclin-B1 →	+0.835	+3.321	.002	.010	3	2
UCEC	GAPDH →	+0.625	+3.321	.015	.009	3	1
UCEC	JNK2 →	+0.220	+2.834	.022	.034	3	1
UCEC	Ku80 →	+0.364	+3.179	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ACC_pS79 by ARX expression — UCEC

Explore this box plot interactively →