ARX

Across TCGA pan-cancer cohorts, ARX RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ARX’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ARX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARX is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KIRC, KIRP, and PRAD are the cancer types where ARX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.439	<.001	9	view →
KIRP	All	All	+0.652	.026	3	view →
PRAD	All	All	+0.669	.010	2	view →
LUSC	Male	II,III,IV	−0.583	.023	2	view →
THCA	Female	All	+0.401	.006	1	view →
LIHC	All	All	+0.136	.049	1	view →
CHOL	All	All	+0.056	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ARX–KIRC

Open the KIRC breakdown →