ARX

Across TCGA cell cohorts, ARX RNA expression is significantly associated with the go_rna of many other GO terms, with 2,462 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ARX-associated GO terms across cancer lineages are Oxidative phosphorylation, Mitochondrial electron transport, NADH to ubiquinone, and Purine nucleotide biosynthetic process. Each is linked with ARX in more than 8 cancer types. Because this analysis shows association rather than direction, both ARX-to-partner and partner-to-ARX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxidative phosphorylation grouped by ARX-low versus ARX-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARX→partner) and Y-score (partner→ARX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Oxidative phosphorylation →	+0.059	+0.058	.009	.006	3	9
BONE	Mitochondrial electron transport, NADH to ubiquinone →	+0.077	+2.009	.001	.006	3	6
BONE	Purine nucleotide biosynthetic process →	+0.070	+3.461	.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of isotype switching to IgE isotypes →	-1.191	-0.089	<.001	.007	3	5
UPPER_AERODIGESTIVE_TRACT	Positive regulation of isotype switching to IgE isotypes →	-1.191	-0.089	<.001	.007	3	5
BONE	Extracellular matrix organization →	-0.226	-2.357	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,462 associations by consensus.

Oxidative phosphorylation by ARX expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →