ARVCF

Across TCGA pan-cancer cohorts, ARVCF mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ARVCF data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ARVCF mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ARVCF expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where ARVCF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.929	0.680	<.001	87	view →
HNSC	DFS	Median	III,IV	0.912	0.683	.001	49	view →
UCEC	DFS	Median	II,III,IV	0.944	0.469	.003	12	view →
LSCC	DFS	Quartile	All	0.904	0.515	.005	8	view →
PDAC	OS	Quartile	II,III,IV	0.706	0.369	.023	5	view →
LUAD	OS	Tertile	All	0.849	0.634	.028	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ARVCF–CCRCC (DFS)

Open the CCRCC breakdown →