ART4

Across TCGA patient cohorts, ART4 mutation is significantly associated with the RNA expression of many other genes, with 4,300 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ART4-associated genes across cancer lineages are KRTAP9-4, RNA5SP160, and RNU6-1274P. Each is linked with ART4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ART4-to-partner and partner-to-ART4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP9-4 grouped by ART4-low versus ART4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ART4→partner) and Y-score (partner→ART4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	KRTAP9-4 →	+0.107	+3.334	<.001	.003	3	3
READ	RNA5SP160 →	+0.627	+4.023	<.001	.005	3	2
READ	RNU6-1274P →	+0.316	+4.341	.003	.007	3	2
READ	MIR552 →	+0.271	+4.341	<.001	.007	3	2
READ	MTND4P30 →	+0.177	+4.542	<.001	.001	3	2
LUSC	RPL23AP72 →	+0.308	+2.823	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,300 associations by consensus.

KRTAP9-4 by ART4 expression — LUSC

Explore this box plot interactively →