ART4

Across TCGA pan-cancer cohorts, ART4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ART4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ART4 RNA is repressed in tumor relative to normal tissue. In most cancer types ART4 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and COAD are the cancer types where ART4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ART4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.937	<.001	11	view →
LUAD	Female	III,IV	−1.882	<.001	11	view →
COAD	All	III,IV	−0.317	<.001	9	view →
HNSC	Male	All	−0.237	<.001	8	view →
LUSC	Female	II,III,IV	−2.360	<.001	7	view →
KIRP	Female	II,III,IV	−1.384	<.001	7	view →
BLCA	All	III,IV	−0.312	.003	7	view →
KICH	All	All	−0.990	<.001	6	view →
BRCA	All	III,IV	−0.981	<.001	6	view →
UCEC	All	All	−0.903	<.001	6	view →
LIHC	All	All	−0.690	.004	3	view →
READ	All	II,III,IV	−0.392	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ART4–THCA

Open the THCA breakdown →