ART1

Across TCGA patient cohorts, ART1 mutation is significantly associated with the RNA expression of many other genes, with 350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ART1-associated genes across cancer lineages are RNU6-993P, MIR4666B, and OR5D17P. Each is linked with ART1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ART1-to-partner and partner-to-ART1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-993P grouped by ART1-low versus ART1-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ART1→partner) and Y-score (partner→ART1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNU6-993P →	+0.534	+4.969	<.001	.009	3	2
GBM	MIR4666B →	+0.643	+7.209	<.001	<.001	3	2
SKCM	OR5D17P →	+0.015	+3.452	.005	.004	3	2
UCEC	SAAL1 →	+0.593	+3.343	.007	.005	3	2
UCEC	CHRNA5 →	+0.830	+3.332	.002	.005	3	2
LUAD	RNU6-841P →	+0.439	+6.333	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 350 associations by consensus.

RNU6-993P by ART1 expression — GBM

Explore this box plot interactively →