ART1

Across TCGA pan-cancer cohorts, ART1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ART1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ART1 RNA is repressed in tumor relative to normal tissue. In most cancer types ART1 is over-expressed in tumor, although a few such as HNSC and LUSC show the opposite, repressed pattern.

HNSC, LUSC, and LUAD are the cancer types where ART1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ART1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−0.995	.002	8	view →
LUSC	Female	All	−0.763	<.001	8	view →
LUAD	Male	All	−0.462	<.001	8	view →
KICH	Male	II,III,IV	−0.385	<.001	7	view →
COAD	All	II,III,IV	−0.076	.014	4	view →
KIRP	Male	All	−0.323	<.001	3	view →
UCEC	All	All	−0.162	.025	2	view →
KIRC	Female	IV	−0.258	.034	1	view →
STAD	Male	IV	+0.140	.019	1	view →
LIHC	All	All	+0.020	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ART1–HNSC

Open the HNSC breakdown →