ARSK

Across TCGA cell cohorts, ARSK mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ARSK-associated genes across cancer lineages are GAPDHS, LHCGR, and H2BC3. Each is linked with ARSK in more than 1 cancer types. Because this analysis shows association rather than direction, both ARSK-to-partner and partner-to-ARSK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDHS grouped by ARSK-low versus ARSK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSK→partner) and Y-score (partner→ARSK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GAPDHS →	+0.079	+3.626	<.001	.006	3	1
LARGE_INTESTINE	LHCGR →	+0.034	+3.882	<.001	.001	3	1
LARGE_INTESTINE	H2BC3 →	+0.179	+3.196	<.001	.007	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1
SKIN	PRMT8 →	+0.706	+3.707	<.001	.009	3	1
SKIN	CCL25 →	+0.085	+4.510	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GAPDHS by ARSK expression — LARGE_INTESTINE

Explore this box plot interactively →