ARSK

Across TCGA pan-cancer cohorts, ARSK RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ARSK’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARSK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARSK is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where ARSK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARSK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.637	<.001	12	view →
THCA	Male	III,IV	−1.328	<.001	11	view →
LIHC	Male	All	+0.723	<.001	8	view →
KICH	All	All	−0.781	<.001	4	view →
BRCA	Female	All	−0.233	.001	4	view →
CHOL	Male	All	+0.994	<.001	3	view →
PRAD	All	All	−0.272	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ARSK–HNSC

Open the HNSC breakdown →