ARSJ

Across TCGA cell cohorts, ARSJ mutation is significantly associated with the RNA expression of many other genes, with 396 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARSJ-associated genes across cancer lineages are CFHR2, ASB17, and WFDC12. Each is linked with ARSJ in more than 2 cancer types. Because this analysis shows association rather than direction, both ARSJ-to-partner and partner-to-ARSJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by ARSJ-low versus ARSJ-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSJ→partner) and Y-score (partner→ARSJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	3
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	2
BLOOD_Leukemia	WFDC12 →	+0.249	+4.874	<.001	.002	3	1
BLOOD_Leukemia	DEFB4A →	+0.123	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	FAM24A →	+0.064	+4.969	<.001	.003	3	1
BLOOD_Lymphoma	FTMT →	+0.277	+5.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 396 associations by consensus.

CFHR2 by ARSJ expression — BLOOD_Leukemia

Explore this box plot interactively →