ARSJ

Across TCGA pan-cancer cohorts, ARSJ RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ARSJ data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ARSJ RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARSJ expression acts as an unfavorable survival marker, although some lineages such as SKCM and KICH show a favorable association.

UVM, ACC, and BLCA are the cancer types where ARSJ RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.301	0.820	<.001	85	view →
ACC	DFS	Tertile	All	0.268	0.739	<.001	70	view →
BLCA	OS	Quartile	All	0.536	0.710	.002	52	view →
SKCM	OS	Quartile	All	0.433	0.246	.001	48	view →
LGG	OS	Median	All	0.746	0.871	<.001	47	view →
KICH	DFS	Median	II,III,IV	1.000	0.602	.009	42	view →
KIRC	OS	Tertile	All	0.687	0.520	.003	36	view →
HNSC	OS	Tertile	All	0.713	0.821	.001	34	view →
SARC	DFS	Quartile	All	0.365	0.596	.001	31	view →
MESO	DFS	Median	All	0.237	0.609	.003	27	view →
LIHC	OS	Quartile	All	0.363	0.641	.001	22	view →
READ	OS	Median	III,IV	0.776	0.301	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ARSJ–UVM (DFS)

Open the UVM breakdown →