Across TCGA cell cohorts, ARSH mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARSH-associated genes across cancer lineages are FAM47B, CHRNA2, and FIGLA. Each is linked with ARSH in more than 1 cancer types. Because this analysis shows association rather than direction, both ARSH-to-partner and partner-to-ARSH results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSH→partner) and Y-score (partner→ARSH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM47B →	+0.016	+5.029	<.001	.006	3	1
SKIN	CHRNA2 →	+0.045	+4.684	<.001	.002	3	1
SKIN	FIGLA →	+0.092	+5.022	<.001	.002	3	1
LARGE_INTESTINE	ADRA1A →	+0.179	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	ECE2 →	+0.340	+4.054	<.001	.004	3	1
LARGE_INTESTINE	HTR1E →	+0.085	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

ARSH survival (RNA) · tumor vs normal (RNA) · all ARSH data types