ARSF

Across TCGA patient cohorts, ARSF mutation is significantly associated with the RNA expression of many other genes, with 1,286 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARSF-associated genes across cancer lineages are RAD51, RNU6-731P, and POLDIP3. Each is linked with ARSF in more than 2 cancer types. Because this analysis shows association rather than direction, both ARSF-to-partner and partner-to-ARSF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by ARSF-low versus ARSF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSF→partner) and Y-score (partner→ARSF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.752	+2.818	<.001	.001	3	3
SKCM	RNU6-731P →	+0.111	+1.514	.009	.002	3	3
UCEC	POLDIP3 →	+0.439	+2.847	.005	.001	3	2
UCEC	L3MBTL2 →	+0.380	+2.595	.001	<.001	3	2
UCEC	OIP5 →	+0.691	+2.807	.003	.003	3	2
UCEC	KXD1 →	+0.397	+3.024	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,286 associations by consensus.

RAD51 by ARSF expression — UCEC

Explore this box plot interactively →