ARSF

Across TCGA pan-cancer cohorts, ARSF RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ARSF’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARSF RNA is repressed in tumor relative to normal tissue. In most cancer types ARSF is over-expressed in tumor, although a few such as HNSC and KIRP show the opposite, repressed pattern.

HNSC, KIRP, and KICH are the cancer types where ARSF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARSF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	−2.092	<.001	12	view →
KIRP	All	III,IV	−2.594	<.001	10	view →
KICH	Female	All	−2.291	<.001	7	view →
LUAD	Female	All	−0.160	<.001	7	view →
BLCA	All	All	−0.680	.036	6	view →
CHOL	All	All	−1.281	<.001	3	view →
PRAD	All	All	−0.371	<.001	2	view →
UCEC	All	All	+0.199	.021	2	view →
THCA	Male	II,III,IV	−0.177	.026	2	view →
COAD	Male	IV	−0.052	.021	2	view →
LUSC	Female	II,III,IV	−0.225	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ARSF–HNSC

Open the HNSC breakdown →