ARSF

Across TCGA patient cohorts, ARSF mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ARSF-associated genes across cancer lineages are Notch1, Annexin-1, and JNK2. Each is linked with ARSF in more than 2 cancer types. Because this analysis shows association rather than direction, both ARSF-to-partner and partner-to-ARSF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ARSF-low versus ARSF-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSF→partner) and Y-score (partner→ARSF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Notch1 →	+0.135	+1.362	.045	.035	3	2
SKCM	Annexin-1 →	+0.513	+3.584	.001	.002	3	2
SKCM	JNK2 →	+0.151	+1.820	.036	.014	3	1
COAD	MEK1 →	+0.381	+2.832	<.001	.035	1	3
SKCM	Smad4 →	+0.084	+2.012	.033	.017	3	1
SKCM	BRD4 →	+0.270	+2.199	.032	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Notch1 by ARSF expression — SKCM

Explore this box plot interactively →