ARPC5L

Across TCGA cell cohorts, ARPC5L RNA expression is significantly associated with the go_rna of many other GO terms, with 3,614 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARPC5L-associated GO terms across cancer lineages are Arp2/3 complex-mediated actin nucleation, Proteasome regulatory particle assembly, and Spliceosomal tri-snRNP complex assembly. Each is linked with ARPC5L in more than 12 cancer types. Because this analysis shows association rather than direction, both ARPC5L-to-partner and partner-to-ARPC5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Arp2/3 complex-mediated actin nucleation grouped by ARPC5L-low versus ARPC5L-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARPC5L→partner) and Y-score (partner→ARPC5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Arp2/3 complex-mediated actin nucleation →	+0.134	+0.727	.001	.001	2	13
LIVER	Proteasome regulatory particle assembly →	+0.149	+0.692	.001	<.001	3	12
PANCREAS	Spliceosomal tri-snRNP complex assembly →	+0.090	+0.768	<.001	<.001	3	11
OESOPHAGUS	Positive regulation of mRNA 3'-end processing →	+0.159	+0.777	.005	.008	2	12
OVARY	Actin nucleation →	+0.129	+0.853	<.001	<.001	3	11
LUNG_SCLC	Dolichol phosphate mannose biosynthetic process →	+0.088	+0.555	.004	.003	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,614 associations by consensus.

Arp2/3 complex-mediated actin nucleation by ARPC5L expression — LUNG_SCLC

Explore this box plot interactively →