ARPC4

Across TCGA patient cohorts, ARPC4 mutation is significantly associated with the RNA expression of many other genes, with 112 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARPC4-associated genes across cancer lineages are ZNF114P1, MIR1225, and UBE2Q2P10. Each is linked with ARPC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARPC4-to-partner and partner-to-ARPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF114P1 grouped by ARPC4-low versus ARPC4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARPC4→partner) and Y-score (partner→ARPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ZNF114P1 →	+0.179	+7.640	<.001	.009	3	2
BLCA	MIR1225 →	+0.468	+7.640	<.001	.009	3	1
CESC	UBE2Q2P10 →	+0.062	+5.010	<.001	.009	3	1
CESC	NCKAP1P1 →	+0.057	+5.201	<.001	.007	3	1
CESC	ANOS2P →	+0.022	+5.539	<.001	.004	3	1
CESC	VENTXP3 →	+0.070	+5.812	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 112 associations by consensus.

ZNF114P1 by ARPC4 expression — BLCA

Explore this box plot interactively →