ARPC4

Across TCGA pan-cancer cohorts, ARPC4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ARPC4 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ARPC4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ARPC4 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRP show a favorable association.

UVM, LIHC, and KICH are the cancer types where ARPC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.746	0.376	<.001	94	view →
LIHC	OS	Median	All	0.416	0.606	<.001	81	view →
KICH	DFS	Median	All	0.785	1.000	.003	76	view →
ACC	DFS	Median	All	0.240	0.687	<.001	76	view →
KIRP	DFS	Tertile	All	0.963	0.848	<.001	66	view →
LGG	OS	Median	All	0.731	0.890	<.001	47	view →
OV	DFS	Tertile	All	0.325	0.425	.005	44	view →
MESO	OS	Tertile	All	0.216	0.425	.005	30	view →
LAML	DFS	Tertile	All	0.411	0.666	.004	30	view →
BLCA	OS	Median	III,IV	0.662	0.494	.003	26	view →
SCLC	OS	Median	All	0.398	1.000	<.001	18	view →
SKCM	DFS	Tertile	All	0.642	0.851	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ARPC4–UVM (DFS)

Open the UVM breakdown →