ARPC1B

Across TCGA pan-cancer cohorts, ARPC1B RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated ARPC1B data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ARPC1B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ARPC1B expression acts as an unfavorable survival marker, although some lineages such as SKCM and THYM show a favorable association.

UVM, ACC, and KIRC are the cancer types where ARPC1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.344	0.786	<.001	149	view →
ACC	DFS	Median	All	0.209	0.709	<.001	122	view →
KIRC	DFS	Median	All	0.748	0.853	<.001	112	view →
LGG	DFS	Median	All	0.325	0.470	<.001	51	view →
LIHC	OS	Tertile	All	0.417	0.590	<.001	50	view →
HNSC	DFS	Median	All	0.654	0.734	.007	44	view →
COAD	DFS	Quartile	II,III,IV	0.632	0.881	.002	39	view →
READ	OS	Median	II,III,IV	0.424	0.775	.002	31	view →
UCS	OS	Tertile	II,III,IV	0.376	0.783	.009	28	view →
LUAD	DFS	Quartile	III,IV	0.540	0.934	.002	28	view →
CESC	DFS	Median	All	0.667	0.810	.005	26	view →
KICH	OS	Median	II,III,IV	0.610	0.963	.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

ARPC1B–UVM (OS)

Open the UVM breakdown →