ARPC1B

Across TCGA pan-cancer cohorts, ARPC1B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ARPC1B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARPC1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARPC1B is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where ARPC1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARPC1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.246	<.001	12	view →
KIRC	Male	IV	+1.392	<.001	12	view →
KIRP	All	IV	+2.974	<.001	11	view →
COAD	Female	III,IV	+0.830	<.001	11	view →
LIHC	Female	II,III,IV	+1.609	<.001	9	view →
STAD	Female	All	+1.861	<.001	8	view →
BLCA	All	All	+0.785	.001	8	view →
BRCA	All	III,IV	+0.864	<.001	6	view →
ESCA	All	All	+2.416	<.001	5	view →
KICH	All	All	−1.173	<.001	5	view →
THCA	Male	All	+0.584	.001	4	view →
READ	All	II,III,IV	+0.580	.006	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ARPC1B–HNSC

Open the HNSC breakdown →