ARNTL2

Across TCGA patient cohorts, ARNTL2 mutation is significantly associated with the RNA expression of many other genes, with 2,135 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARNTL2-associated genes across cancer lineages are SCGB1C2, MFSD14C, and OR13C3. Each is linked with ARNTL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARNTL2-to-partner and partner-to-ARNTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1C2 grouped by ARNTL2-low versus ARNTL2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARNTL2→partner) and Y-score (partner→ARNTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SCGB1C2 →	+0.760	+4.169	<.001	.001	3	3
UCEC	MFSD14C →	+0.735	+2.534	<.001	.001	3	2
PRAD	OR13C3 →	+0.037	+5.324	<.001	.003	3	2
PRAD	RNU2-52P →	+0.417	+4.972	<.001	.002	3	2
UCEC	KIF9-AS1 →	+0.470	+2.764	<.001	.002	3	2
UCEC	FRG1HP →	+0.432	+2.032	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,135 associations by consensus.

SCGB1C2 by ARNTL2 expression — LUAD

Explore this box plot interactively →