ARNT

Across TCGA pan-cancer cohorts, ARNT mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ARNT data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ARNT mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ARNT expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, UCEC, and CCRCC are the cancer types where ARNT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.987	0.847	<.001	25	view →
UCEC	DFS	Median	All	0.933	1.000	.015	6	view →
CCRCC	DFS	Median	All	0.558	0.887	.045	1	view →
LSCC	DFS	Median	All	0.977	0.907	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ARNT–LUAD (DFS)

Open the LUAD breakdown →