ARNT

Across TCGA pan-cancer cohorts, ARNT RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ARNT’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARNT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARNT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and THCA are the cancer types where ARNT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARNT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.578	<.001	10	view →
KICH	Female	All	−1.790	<.001	8	view →
THCA	All	II,III,IV	−0.503	<.001	8	view →
LIHC	Male	All	+0.764	<.001	5	view →
UCEC	All	All	−0.707	<.001	4	view →
COAD	Female	All	−0.375	.002	4	view →
LUSC	Male	All	−0.326	.002	4	view →
CHOL	All	All	+1.048	.002	2	view →
LUAD	Female	II,III,IV	−0.441	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ARNT–HNSC

Open the HNSC breakdown →