ARNT

Across TCGA patient cohorts, ARNT protein abundance is significantly associated with the RNA expression of many other genes, with 6,246 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ARNT-associated genes across cancer lineages are PRUNE1, YY1, and PIGC. Each is linked with ARNT in more than 5 cancer types. Because this analysis shows association rather than direction, both ARNT-to-partner and partner-to-ARNT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARNT versus PRUNE1 in UCEC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARNT→partner) and Y-score (partner→ARNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRUNE1 →	+0.655	+0.306	<.001	<.001	2	6
LUAD	YY1 →	+0.434	+0.258	<.001	<.001	3	4
UCEC	PIGC →	+0.513	+0.228	.002	.004	3	4
LSCC	VPS45 →	+0.475	+0.249	.002	<.001	3	4
LSCC	POGK →	+0.544	+0.207	<.001	<.001	3	4
LSCC	USP21 →	+0.534	+0.141	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,246 associations by consensus.

ARNT vs PRUNE1 — UCEC

Explore this scatter interactively →