ARNT

Across TCGA cell cohorts, ARNT mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARNT-associated genes across cancer lineages are KIF2B, PSKH2, and ACTL9. Each is linked with ARNT in more than 1 cancer types. Because this analysis shows association rather than direction, both ARNT-to-partner and partner-to-ARNT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF2B grouped by ARNT-low versus ARNT-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARNT→partner) and Y-score (partner→ARNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KIF2B →	+0.113	+5.977	<.001	.001	3	1
LUNG_NSCLC_LUAD	PSKH2 →	+0.028	+4.887	<.001	.009	3	1
STOMACH	ACTL9 →	+0.020	+5.285	<.001	.003	3	1
STOMACH	CCL23 →	+0.120	+5.285	<.001	.003	3	1
BLOOD_Leukemia	DCLK3 →	+0.222	+3.769	<.001	.008	3	1
BLOOD_Leukemia	TBPL2 →	+0.104	+4.044	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

KIF2B by ARNT expression — SOFT_TISSUE

Explore this box plot interactively →