ARMC8

Across TCGA pan-cancer cohorts, ARMC8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ARMC8 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ARMC8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARMC8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

COAD, HNSC, and LSCC are the cancer types where ARMC8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.930	1.000	.025	42	view →
HNSC	DFS	Tertile	II,III,IV	0.812	0.502	.001	27	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.848	.015	6	view →
LUAD	DFS	Median	III,IV	0.571	0.883	.027	4	view →
CCRCC	DFS	Quartile	III,IV	0.428	0.748	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ARMC8–COAD (DFS)

Open the COAD breakdown →