ARMC8

Across TCGA pan-cancer cohorts, ARMC8 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ARMC8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARMC8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARMC8 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where ARMC8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARMC8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.683	<.001	11	view →
THCA	Male	III,IV	−0.789	<.001	10	view →
LIHC	Female	II,III,IV	+0.768	<.001	9	view →
CHOL	Male	All	+1.558	<.001	5	view →
KICH	All	All	−0.766	<.001	5	view →
KIRC	Male	II,III,IV	−0.294	.006	4	view →
LUAD	Female	II,III,IV	−0.393	<.001	3	view →
READ	All	All	−0.417	.005	2	view →
LUSC	All	All	+0.284	.001	2	view →
COAD	All	All	−0.181	.028	2	view →
BLCA	All	IV	−0.347	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ARMC8–HNSC

Open the HNSC breakdown →