ARMC8

Across TCGA patient cohorts, ARMC8 mutation is significantly associated with the RNA expression of many other genes, with 2,111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARMC8-associated genes across cancer lineages are RNA5SP413, LINC00583, and GNG5P1. Each is linked with ARMC8 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARMC8-to-partner and partner-to-ARMC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by ARMC8-low versus ARMC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARMC8→partner) and Y-score (partner→ARMC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP413 →	+0.952	+1.791	<.001	<.001	3	4
HNSC	LINC00583 →	+0.047	+4.023	.002	.009	3	3
SKCM	GNG5P1 →	+0.159	+3.578	<.001	.007	3	3
LUSC	RNA5SP423 →	+0.542	+4.733	<.001	.004	3	3
BRCA	RNA5SP414 →	+0.216	+8.471	<.001	.005	3	2
CESC	HIGD1AP6 →	+0.320	+4.200	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,111 associations by consensus.

RNA5SP413 by ARMC8 expression — UCEC

Explore this box plot interactively →