ARMC8

Across TCGA patient cohorts, ARMC8 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARMC8-associated genes across cancer lineages are Annexin_VII, ATM, and eIF4E. Each is linked with ARMC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARMC8-to-partner and partner-to-ARMC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin_VII grouped by ARMC8-low versus ARMC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARMC8→partner) and Y-score (partner→ARMC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin_VII →	-0.116	-1.874	.011	.049	3	3
UCEC	ATM →	-0.369	-1.986	.013	.029	3	3
UCEC	eIF4E →	+0.147	+1.652	.034	.006	3	2
UCEC	MEK1 →	+0.321	+1.652	.007	.006	3	2
UCEC	S6_pS240_S244 →	+0.314	+2.222	.019	.010	3	2
UCEC	ASNS →	+0.271	+1.415	.023	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Annexin_VII by ARMC8 expression — UCEC

Explore this box plot interactively →