ARMC8

Across TCGA cell cohorts, ARMC8 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARMC8-associated genes across cancer lineages are REG1B, TLX3, and PPDPFL. Each is linked with ARMC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARMC8-to-partner and partner-to-ARMC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by ARMC8-low versus ARMC8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARMC8→partner) and Y-score (partner→ARMC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	REG1B →	+0.126	+5.415	<.001	.004	3	1
LARGE_INTESTINE	TLX3 →	+0.685	+3.845	<.001	.003	3	1
LARGE_INTESTINE	PPDPFL →	+0.040	+3.632	<.001	.003	3	1
LARGE_INTESTINE	HTR1E →	+0.074	+3.345	<.001	.007	3	1
LARGE_INTESTINE	UTF1 →	+0.013	+3.632	.002	.003	3	1
LARGE_INTESTINE	C10orf53 →	+0.021	+4.632	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

REG1B by ARMC8 expression — SKIN

Explore this box plot interactively →