ARMC4

Across TCGA pan-cancer cohorts, ARMC4 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated ARMC4 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ARMC4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARMC4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and LIHC are the cancer types where ARMC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.303	0.717	<.001	46	view →
UCEC	DFS	Median	All	0.940	0.615	.007	24	view →
LIHC	DFS	Median	II,III,IV	0.069	0.429	<.001	21	view →
OV	DFS	Median	II,III,IV	0.195	0.541	.015	18	view →
THYM	DFS	Median	All	0.123	0.871	<.001	12	view →
STAD	DFS	Median	All	0.279	0.713	.009	9	view →
GBM	DFS	Median	All	0.043	0.243	.003	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SARC	DFS	Median	All	0.179	0.594	.031	3	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	OS	Median	IV	0.140	0.621	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

ARMC4–HNSC (DFS)

Open the HNSC breakdown →