ARMC4

Across TCGA pan-cancer cohorts, ARMC4 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ARMC4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ARMC4 RNA is repressed in tumor relative to normal tissue. In most cancer types ARMC4 is over-expressed in tumor, although a few such as LUSC and BLCA show the opposite, repressed pattern.

LUSC, BLCA, and LUAD are the cancer types where ARMC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARMC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−2.035	<.001	8	view →
BLCA	Male	IV	−1.250	<.001	8	view →
LUAD	All	II,III,IV	−1.064	<.001	8	view →
KICH	All	All	+0.601	<.001	5	view →
STAD	All	All	−0.307	.009	3	view →
UCEC	All	All	−1.094	.023	2	view →
CHOL	Female	All	+0.723	.036	2	view →
COAD	All	II,III,IV	−0.145	.015	2	view →
READ	Female	All	−0.668	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ARMC4–LUSC

Open the LUSC breakdown →