ARMC4

Across TCGA patient cohorts, ARMC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,164 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible ARMC4-associated GO terms across cancer lineages are Regulation of smoothened signaling pathway, Establishment of protein localization to chromosome, and Regulation of organelle assembly. Each is linked with ARMC4 in more than 23 cancer types. Because this analysis shows association rather than direction, both ARMC4-to-partner and partner-to-ARMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of smoothened signaling pathway grouped by ARMC4-low versus ARMC4-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARMC4→partner) and Y-score (partner→ARMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of smoothened signaling pathway →	+0.079	+0.326	<.001	<.001	3	24
STAD	Establishment of protein localization to chromosome →	+0.062	+0.326	<.001	<.001	3	24
ESCA	Regulation of organelle assembly →	+0.057	+0.208	<.001	<.001	3	23
STAD	Regulation of calcium ion export across plasma membrane →	+0.052	+0.256	<.001	<.001	3	23
STAD	Cytoplasmic translational initiation →	+0.065	+0.257	<.001	<.001	3	23
STAD	Viral gene expression →	+0.076	+0.283	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,164 associations by consensus.

Regulation of smoothened signaling pathway by ARMC4 expression — ESCA

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