ARL8B

Across TCGA patient cohorts, ARL8B mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL8B-associated genes across cancer lineages are EGFR_pY1068, ACC_pS79, and ACC1. Each is linked with ARL8B in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL8B-to-partner and partner-to-ARL8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ARL8B-low versus ARL8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL8B→partner) and Y-score (partner→ARL8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.228	-2.906	.032	.001	3	1
UCEC	ACC_pS79 →	+0.400	+2.222	.006	.011	3	1
UCEC	ACC1 →	+0.487	+3.183	.001	.009	3	1
UCEC	mTOR_pS2448 →	-0.139	-2.308	.028	.033	3	1
UCEC	Notch1 →	+0.130	+3.013	.029	.018	3	1
UCEC	PCNA →	+0.189	+2.222	.039	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by ARL8B expression — UCEC

Explore this box plot interactively →