ARL5C

Across TCGA patient cohorts, ARL5C mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. ESCA shows the largest number of these associations.

The most reproducible ARL5C-associated genes across cancer lineages are OR5I1, PRAMEF28P, and RNU6-1138P. Each is linked with ARL5C in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL5C-to-partner and partner-to-ARL5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5I1 grouped by ARL5C-low versus ARL5C-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL5C→partner) and Y-score (partner→ARL5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	OR5I1 →	+0.222	+5.450	<.001	.004	3	2
UCEC	PRAMEF28P →	+0.079	+4.136	.002	.001	3	1
COAD	RNU6-1138P →	+0.463	+5.790	<.001	.003	3	1
COAD	CNN2P2 →	+0.070	+6.122	<.001	.002	3	1
COAD	LINC00229 →	+0.690	+5.283	<.001	.006	3	1
COAD	RPS14P7 →	+0.206	+5.602	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

OR5I1 by ARL5C expression — ESCA

Explore this box plot interactively →