ARL5C

Across TCGA pan-cancer cohorts, ARL5C RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ARL5C’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where ARL5C RNA is repressed in tumor relative to normal tissue. In most cancer types ARL5C is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, KICH, and COAD are the cancer types where ARL5C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARL5C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	−0.055	<.001	6	view →
KICH	All	All	−0.018	.016	4	view →
COAD	Male	III,IV	−0.018	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

ARL5C–BRCA

Open the BRCA breakdown →