ARL5A

Across TCGA patient cohorts, ARL5A mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL5A-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and eEF2. Each is linked with ARL5A in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL5A-to-partner and partner-to-ARL5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ARL5A-low versus ARL5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL5A→partner) and Y-score (partner→ARL5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.559	+1.807	.022	.027	3	2
UCEC	14-3-3_beta →	-0.110	-1.794	.007	.027	3	1
UCEC	eEF2 →	+0.382	+3.169	.009	.018	3	1
UCEC	EGFR →	-0.173	-3.000	.008	.036	3	1
UCEC	FoxM1 →	+0.255	+1.807	.017	.027	3	1
UCEC	GATA6 →	-0.183	-1.693	.005	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by ARL5A expression — UCEC

Explore this box plot interactively →