ARL2-SNX15

Across TCGA pan-cancer cohorts, ARL2-SNX15 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ARL2-SNX15’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARL2-SNX15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARL2-SNX15 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

HNSC, LUAD, and BRCA are the cancer types where ARL2-SNX15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARL2-SNX15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.036	<.001	10	view →
LUAD	All	All	+0.017	.001	5	view →
BRCA	All	II,III,IV	−0.006	.040	2	view →
LUSC	Male	All	+0.015	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ARL2-SNX15–HNSC

Open the HNSC breakdown →