ARL14EPL

Across TCGA pan-cancer cohorts, ARL14EPL RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ARL14EPL data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ARL14EPL RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ARL14EPL expression acts as an unfavorable survival marker, although some lineages such as SKCM and BRCA show a favorable association.

KIRC, LUSC, and THYM are the cancer types where ARL14EPL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.817	0.903	<.001	149	view →
LUSC	OS	Median	All	0.609	0.731	<.001	106	view →
THYM	OS	Tertile	All	0.487	0.947	<.001	81	view →
KIRP	DFS	Median	II,III,IV	0.199	0.832	<.001	65	view →
MESO	OS	Tertile	II,III,IV	0.306	0.557	.006	57	view →
HNSC	OS	Quartile	II,III,IV	0.666	0.791	.003	52	view →
LGG	DFS	Median	All	0.633	0.814	<.001	50	view →
SKCM	OS	Median	All	0.423	0.271	<.001	43	view →
PAAD	DFS	Median	All	0.232	0.485	.001	38	view →
LUAD	DFS	Quartile	II,III,IV	0.514	0.794	.003	28	view →
STAD	DFS	Quartile	II,III,IV	0.493	0.741	.005	27	view →
GBM	OS	Quartile	All	0.192	0.335	.019	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ARL14EPL–KIRC (OS)

Open the KIRC breakdown →