ARL14EPL

Across TCGA pan-cancer cohorts, ARL14EPL RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ARL14EPL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ARL14EPL RNA is repressed in tumor relative to normal tissue. In most cancer types ARL14EPL is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where ARL14EPL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARL14EPL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−0.358	<.001	12	view →
THCA	Male	II,III,IV	+0.514	<.001	10	view →
HNSC	All	II,III,IV	+0.151	.010	5	view →
KICH	Female	All	−0.394	<.001	3	view →
UCEC	All	All	+0.226	.046	2	view →
LUSC	Female	All	−0.204	<.001	2	view →
ESCA	All	II,III,IV	+0.100	.037	2	view →
LUAD	Female	All	−0.101	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ARL14EPL–KIRC

Open the KIRC breakdown →