ARL14EP

Across TCGA pan-cancer cohorts, ARL14EP RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ARL14EP data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ARL14EP RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ARL14EP expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

BRCA, KIRC, and READ are the cancer types where ARL14EP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.972	0.924	<.001	90	view →
KIRC	OS	Tertile	All	0.774	0.580	<.001	78	view →
READ	DFS	Tertile	II,III,IV	0.736	0.233	.001	74	view →
LIHC	OS	Tertile	All	0.721	0.870	<.001	68	view →
LUAD	DFS	Tertile	All	0.821	0.730	.007	26	view →
KIRP	DFS	Tertile	IV	0.043	0.529	.010	22	view →
ESCA	DFS	Tertile	IV	0.143	0.704	.024	18	view →
SKCM	OS	Median	III,IV	0.782	0.600	.007	15	view →
UCEC	DFS	Median	III,IV	0.840	0.744	.020	12	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	11	view →
KICH	DFS	Quartile	III,IV	0.374	1.000	.025	8	view →
ACC	DFS	Quartile	All	0.235	0.706	.007	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ARL14EP–BRCA (DFS)

Open the BRCA breakdown →