ARL14EP

Across TCGA pan-cancer cohorts, ARL14EP mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ARL14EP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARL14EP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ARL14EP is over-expressed in tumor.

HNSC, CCRCC, and LSCC are the cancer types where ARL14EP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARL14EP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.261	<.001	11	view →
CCRCC	Male	All	+0.260	<.001	10	view →
LSCC	Male	All	+0.323	<.001	9	view →
LUAD	Female	All	+0.204	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ARL14EP–HNSC

Open the HNSC breakdown →